Harrison's Principles of Internal Medicine by Dan Longo, Anthony Fauci, Dennis Kasper, Stephen Hauser

The most trusted textbook in medicine -- featuring the acclaimed Harrison's DVD with 57 additional chapters and exclusive video and tutorials

Extensively revised and expanded by the world's leading physicians, Harrison's Principles of Internal Medicine, 18e continues to set the standard as the pinnacle of current medical knowledge and practice, offering the definitive review of disease mechanisms and management.

CURRENT
All chapters have been completely updated to reflect the latest knowledge and evidence, and important new chapters have been added, including: "Systems Biology in Health and Disease," "The Human Microbiome," "The Biology of Aging," and "Neuropsychiatric Illnesses in War Veterans."

CONNECTED
Harrison's covers more global aspects of medicine than any other textbook, and features such chapters as "Global Issues in Medicine," by Jim Yong Kim, Paul Farmer, and Joseph Rhatigan, and new to the 18th edition, "Primary Care in Low and Middle Income Countries."

COMPREHENSIVE
No other resource delivers coverage of disease mechanisms and management like Harrison's, including world-renowned chapters on HIV/AIDS, STEMI and non-STEMI myocardial infarction, cancer biology, multiple sclerosis, and diabetes.

The Harrison's Multi-Media DVD' Better Than Ever!
The Harrison's DVD has been expanded to include an extensive video demonstration of the neurological physical examination, and video tutorials on how to perform essential clinical procedures, including:

1. Thoracentesis
2. Abdominal Paracentesis
3. Endotracheal Intubation
4. Central Venous Catheter Placement

57 additional chapters and more than 2,000 images make the companion DVD an essential part of every physician's education, practice, and lifelong learning.The DVD also features PowerPoint presentations from fifty chapters to facilitate classroom lectures, and a free trial subscription to AccessMedicine.com including Harrison's Online.

Harrison's 18e is proud to present a tribute to longtime editor, Eugene Braunwald, MD for his outstanding and continuing contributions to medical knowledge and practice.

Table Of Contents:

Chapters beginning with "e" are to be found on the DVD
Summaries of Chapters e1 to e57
Contributors
Preface

PART 1: INTRODUCITON TO CLINICAL MEDICINE

1. The Practice of Medicine, The Editors
2. Global Issues in Medicine, Jim Yong Kim, Paul Farmer, and Joseph Rhatigan
3. Decision-Making in Clinical Medicine, Daniel B. Mark, John B. Wong
4. Screening and Prevention of Disease, Gary J. Martin
5. Principles of Clinical Pharmacology, Dan M. Roden
6. Women's Health, Andrea Dunaif
7. Medical Disorders During Pregnancy, Robert L. Barbieri and John T. Repke
8. Medical Evaluation of the Surgical Patient, Wei C. Lau, Kim A. Eagle
9. Palliative and End-of-Life Care, Ezekiel J. Emanuel
10. The Safety and Quality of Health Care, David W. Bates
e1. Primary Care in Low- and Middle-Income Countries, Tim Evans, Kumanan Rasanathan
e2. Complementary, Alternative, and Integrative Medicine, Josephine P. Briggs, Stephen E. Straus
e3. The Economics of Medical Care, Joseph P. Newhouse
e4. Racial and Ethnic Disparities in Health Care, Joseph R. Betancourt, Alexander R. Green
e5. Ethical Issues in Clinical Medicine, Bernard Lo
e6. Neoplasia During Pregnancy, Dan L. Longo

PART 2: CARDINAL MANIFESTATIONS AND PRESENTATION OF DISEASES
Section 1: Pain

11. Pain: Pathophysiology and Management, James P. Rathmell, Howard L. Fields
12. Chest Discomfort, Thomas H. Lee
13. Abdominal Pain, William Silen
14. Headache, Peter J. Goadsby, Neil H. Raskin
15. Back and Neck Pain, John W. Engstrom, Richard A. Deyo

Section 2: Alterations in Body Temperature

16. Fever and Hyperthermia, Charles A. Dinarello, Reuven Porat
17.Fever and Rash, Elaine T. Kaye, Kenneth M. Kaye
e7. Atlas of Rashes Associated with Fever, Kenneth M. Kaye, Elaine T. Kaye
18. Fever of Unknown Origin, Jeffrey A. Gelfand, Michael V. Callahan
19. Hypothermia and Frostbite, Daniel F. Danzl

Section 3: Nervous System Dysfunction

20. Syncope, Roy Freeman
21. Dizziness and Vertigo, Mark F. Walker, Robert B. Daroff
22. Weakness and Paralysis, Michael J. Aminoff
23. Numbness, Tingling, and Sensory Loss, Michael J. Aminoff, Arthur K. Asbury
24. Gait and Balance Disorders, Lewis Sudarsky
e8. Video Library of Gait Disorders, Gail Kang, Nicholas B. Galifianakis, Michael Geschwind
25. Confusion and Delirium, S. Andrew Josephson, Bruce L. Miller
26. Aphasia, Memory Loss, and Other Focal Cerebral Disorders, M.-Marsel Mesulam
e9. Memory Loss, Bruce L. Miller, Indre V. Viskontas
e10. Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders, Maria Luis Gorno-Tempini, Jeninfer Ogar, Joel Kramer, Bruce Miller, Gil Rabinovici, and Camille Tartaglia
27. Sleep Disorders, Charles A. Czeisler, John W. Winkelman, Gary S. Richardson

Section 4: Disorders of Eyes, Ears, Nose, and Throat

28. Disorders of the Eye, Jonathan C. Horton
e11. Video Library of Neuro-Ophthalmology, Shirley H. Wray
29. Disorders of Smell and Taste, Richard L. Doty, Steven M. Bromley
30. Disorders of Hearing, Anil K. Lalwani
31. Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Tract Infections, Michael A. Rubin, Larry C. Ford, Ralph Gonzales
32. Oral Manifestations of Disease, Samuel C. Durso
e12. Atlas of Oral Manifestations of Disease, Samuel C. Durso, Janet A. Yellowitz

Section 5: Alterations in Circulatory and Respiratory Functions

33. Dyspnea, Richard M. Schwartzstein
34. Cough and Hemoptysis, Patricia Kritek, Christopher Fanta
35. Hypoxia and Cyanosis, Joseph Loscalzo
36. Edema, Eugene Braunwald, Joseph Loscalzo
e13. Approach to the Patient with a Heart Murmur, Patrick T. O'Gara, Joseph Loscalzo
37. Palpitations, Joseph Loscalzo

Section 6: Alterations in Gastrointestinal Function

38. Dysphagia, Ikuo Hirano, Peter J. Kahrilas
39. Nausea, Vomiting, and Indigestion, William L. Hasler
40. Diarrhea and Constipation, Michael Camilleri, Joseph A. Murray
41. Gastrointestinal Bleeding, Loren Laine
42. Jaundice, Daniel S. Pratt, Marshall M. Kaplan
43. Abdominal Swelling and Ascites, Kathleen E. Corey, Lawrence S. Friedman

Section 7: Alterations in Renal and Urinary Tract Function

44. Azotemia and Urinary Abnormalities, Julie Lin, Bradley M. Denker
e14. Atlas of Urinary Sediments and Renal Biopsies, Agnes B. Fogo, Eric G. Neilson
45. Fluid and Electrolyte Disturbances, David B. Mount
e15. Fluid and Electrolyte Imbalances and Acid-Base Disturbances: Case Examples, David B. Mount, Thomas D. Dubose, Jr.
46. Hypercalcemia and Hypocalcemia, Sundeep Khosla
47. Acidosis and Alkalosis, Thomas D. Dubose, Jr.

Section 8: Alterations in Sexual Function and Reproduction

48. Sexual Dysfunction, Kevin T. McVary
49. Hirsutism and Virilization, David A. Ehrmann
50. Menstrual Disorders and Pelvic Pain, Janet E. Hall

Section 9: Alterations in the Skin

51. Approach to the Patient with a Skin Disorder, Thomas J. Lawley, Kim B. Yancey
52. Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders, Leslie P. Lawley, Calvin O. McCall, Thomas J. Lawley
53. Skin Manifestations of Internal Disease, Jean L. Bolognia, Irwin M. Braverman (ed. Fauci)
54. Immunologically Mediated Skin Diseases, Kim B. Yancey, Thomas J. Lawley
55. Cutaneous Drug Reactions, Kanada Shinkai, Jean-Claude Roujeau, Robert S. Stern, Bruce U. Wintroub
56. Photosensitivity and Other Reactions to Light, Alexander G. Marneros, David R. Bickers
e16. Atlas of Skin Manifestations of Internal Disease, Thomas J. Lawley, Robert A. Swerlick

Section 10: Hematologic Alterations

57. Anemia and Polycythemia, John W. Adamson, Dan L. Longo
58. Bleeding and Thrombosis, Barbara Konkle
59. Enlargement of Lymph Nodes and Spleen
60. Disorders of Granulocytes and Monocytes, Steven M. Holland, John I. Gallin
e17. Atlas of Hematology and Analysis of Peripheral Blood Smears, Dan L. Longo

PART 3: GENES, THE ENVIRONMENT, AND DISEASE

61. Principles of Human Genetics, J. Larry Jameson, Peter Kopp
62. Chromosome Disorders, Stuart Schwartz, Terry Hassold
63. The Practice of Genetics in Clinical Medicine, Susan Miesfeldt, J. Larry Jameson
e18. Mitochondrial DNA and Heritable Traits and Diseases, Karl Skorecki, Hanna Mandel
64. The Human Microbiome, Jeffrey I. Gordon, Rob Knight
e19. Systems Biology in Health and Disease, Joseph Loscalzo

PART 4: REGENERATIVE MEDICINE

65. Stem Cell Biology, Minoru S. H. Ko
66. Hematopoietic Stem Cells, David T. Scadden, Dan L. Longo
67. Applications of Stem Cell Biology in Clinical Medicine, John A. Kessler
68. Gene Therapy in Clinical Medicine, Katherine A> High
69. Tissue Engineering, David M. Hoganson, Howard I. Pryor, II, Joseph P. Vacanti

PART 5: AGING

70. World Demography of Aging, Richard Suzman
71. The Biology of Aging, George M. Martin
72. Clinical Problems of Aging, Luigi Ferrucci, Stephanie Studenski

PART 6: NUTRITION

73. Nutrient Requirements and Dietary Assessment, Johanna Dwyer
74. Vitamin and Trace Mineral Deficiency and Excess, Robert M. Russell, Paolo M. Suter
75. Malnutrition and Nutritional Assessment, Douglas C. Heimburger
76. Enteral and Parenteral Nutrition Therapy, Bruce R. Bistrian, David F. Driscoll
77. Biology of Obesity, Jeffrey S. Flier, Eleftheria Maratos-Flier
78. Evaluation and Management of Obesity, Robert F. Kushner
79. Eating Disorders, B. Timothy Walsh, Evelyn Attia
80. Involuntary Weight Loss, Russell G. Robertson, J. Larry Jameson

PART 7: ONCOLOGY AND HEMATOLOGY
Section 1: Neoplastic Disorders

81. Approach to the Patient with Cancer, Dan L. Longo
82. Prevention and Early Detection of Cancer, Jennifer M. Croswell, Otis W. Brawley, Barnett S. Kramer
83. Cancer Genetics, Pat J. Morin, Jeffrey M. Trent, Francis S. Collins, Bert Vogelstein
84. Cancer Cell Biology and Angiogenesis, Robert G. Fenton, Dan L. Longo
85. Principles of Cancer Treatment, Edward A. Sausville, Dan L. Longo
86. Infections in Patients with Cancer, Robert Finberg
87. Cancer of the Skin, Walter J. Urba, Carl V. Washington, Hari Nadiminti
88. Head and Neck Cancer, Everett E. Vokes
89. Neoplasms of the Lung, Leora Horn, William Pao, David H. Johnson
90. Breast Cancer, Marc E. Lippman
91. Gastrointestinal Tract Cancer, Robert J. Mayer
92. Tumors of the Liver and Biliary Tree, Brian I. Carr
93. Pancreatic Cancer, Irene Chong, David Cunningham
94. Bladder and Renal Cell Carcinomas, Howard I. Scher, Robert J. Motzer
95. Benign and Malignant Diseases of the Prostate, Howard I. Scher
96. Testicular Cancer, Robert J. Motzer, George J. Bosl
97. Gynecologic Malignancies, Michael V. Seiden
98. Soft Tissue and Bone Sarcomas and Bone Metastases, Shreyaskumar R. Patel, Robert S. Benjamin
99. Carcinoma of Unknown Primary, Gauri R. Varadhachary, James L. Abbruzzese
100. Paraneoplastic Syndromes: Endocrinologic/Hematologic, J. Larry Jameson, Dan L. Longo
101. Paraneoplastic Neurologic Syndromes, Josep Dalmau, Myrna R. Rosenfeld
e20. Thymoma, Dan L. Longo
102. Late Consequences of Cancer and Its Treatment, Carl E. Freter, Dan L. Longo

Section 2: Hematopoietic Disorders

103. Iron Deficiency and Other Hypoproliferative Anemias, John W. Adamson
104. Disorders of Hemoglobin, Edward J. Benz, Jr.
105. Megaloblastic Anemias, A. Victor Hoffbrand
106. Hemolytic Anemias and Anemia Due to Acute Blood Loss, Lucio Luzzatto
107. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes, Neal S. Young
108. Polycythemia Vera and Other Myeloproliferative Diseases, Jerry L. Spivak
109. Acute and Chronic Myeloid Leukemia, Meir Wetzler, Guido Marcucci, and Clara D. Bloomfield
110. Malignancies of Lymphoid Cells, Dan L. Longo
e21. Less Common Hematologic Malignancies, Dan L. Longo
111. Plasma Cell Disorders, Nikhil C. Munshi, Dan L. Longo, Kenneth C. Anderson
112. Amyloidosis, David C. Seldin, Martha Skinner
113. Transfusion Biology and Therapy, Jeffery S. Dzieczkowski, Kenneth c. Anderson
114. Hematopoietic Cell Transplantation, Frederick R. Appelbaum

Section 3: Disorders of Hemostasis

115. Disorders of Platelets and Vessel Wall, Barbara Konkle
116. Coagulation Disorders, Valder R. Arruda, Katherine A. High
117. Arterial and Venous Thrombosis, Jane E. Freedman, Joseph Loscalzo
118. Antiplatelet Anticoagulant and Fibrinolytic Drugs, Jeffrey I. Weitz

PART 8: INFECTIOUS DISEASES
Section 1: Basic Considerations in Infectious Diseases

119. Introduction to Infectious Diseases: Host-Pathogen Interactions, Lawrence C. Madoff, Dennis L. Kasper
120. Molecular Mechanisms of Microbial Pathogenesis, Gerald B. Pier
121. Approach to the Acutely Ill Infected Febrile Patient, Tamar F. Barlam, Dennis L. Kasper
122. Immunization Principles and Vaccine Use, Anne Schuchat, Lisa A. Jackson
123. Health Recommendations for International Travel, Jay S. Keystone, Phyllis E. Kozarsky
e22. Laboratory Diagnosis of Infectious Diseases, Alexander J. McAdam, Andrew B. Onderdonk

Section 2: Clinical Syndromes: Community-Acquired Infections

124. Infective Endocarditis, Adolf W. Karchmer
125. Infections of the Skin, Muscles, and Soft Tissues, Dennis L. Stevens
126. Osteomyelitis, Alan D. Tice
127. Intraabdominal Infections and Abscesses, Miriam J. Baron, Dennis L. Kasper
128. Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning, Regina C. LaRocque, Edward T. Ryan, Stephen B. Calderwood
129. Clostridium difficile Infection, Including Pseudomembranous Colitis, Dale N. Gerding, Stuart Johnson
130. Sexually Transmitted Infections: Overview and Clinical Approach, Jeanne M. Marrazzo, King K. Holmes
e23. Infectious Complications of Burns, Lawrence C. Madoff, Florencia Pereyra
e24. Infectious Complications of Bites, Lawrence C. Madoff, Florencia Pereyra

Section 3: Clinical Syndromes: Health Care-Associated Infections

131. Health Care-Associated Infections, Robert A. Weinstein
132. Infections in Transplant Recipients, Robert Finberg, Joyce Fingeroth

Section 4: Approach to Therapy for Bacterial Diseases

133. Treatment and Prophylaxis of Bacterial Infections, Gordon L. Archer, Ronald E. Polk

Section 5: Diseases Caused by Gram-Positive Bacteria

134. Pneumococcal Infections, David Goldblatt, Katherine L. O'Brien
135. Staphylococcal Infections, Franklin D. Lowy
136. Streptococcal Infections, Michael R. Wessels
137. Enterococcal Infections, Cesar A. Arias, Barbara E. Murray
138. Diphtheria and Other Infections Caused by Corynebacteria and Related Species, William R. Bishai, John R. Murphy
139. Listeria monocytogenes Infections, Elizabeth L. Hohmann, Daniel A. Portnoy
140. Tetanus, C. Louise Thwaites, Lam Minh Yen
141. Botulism, Jeremy Sobel, Susan Maslanka
142. Gas Gangrene and Other Clostridial Infections, Amy E. Bryant, Dennis L. Stevens

Section 6: Diseases Caused by Gram-Negative Bacteria

143. Meningococcal Infections, Andrew J. Pollard
144. Gonococcal Infections, Sanjay Ram, Peter A. Rice
145. Haemophilus and Moraxella Infections, Timothy F. Murphy
146. Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria, Tamar F. Barlam, Dennis L. Kasper
147. Legionella Infections, Miguel Sabria, Victor L. Yu
148. Pertussis and Other Bordetella Infections, Scott A. Halperin
149. Diseases Caused by Gram-Negative Enteric Bacilli, Thomas A. Russo, James R. Johnson
150. Acinetobacter Infections, David L. Paterson, Anton Y. Peleg
151. Helicobacter pylori Infections, John C. Atherton, Martin J. Blaser
152. Infections Due to Pseudomonas Species and Related Organisms, Reuben Ramphal
153. Salmonellosis, David A. Pegues, Samuel I. Miller
154. Shigellosis, David A. Pegues, Samuel I. Miller
155. Infections Due to Campylobacter
and Related Organisms, Martin J. Blaser
156. Cholera and Other Vibrioses, Matthew K. Waldor, Edward T. Ryan
157. Brucellosis, Michael J. Corbel, Nicholas J. Beeching
158. Tularemia, Richard F. Jacobs, Gordon E. Schutze
159. Plague and Other Yersinia Infections, Michael B. Prentice
160. Bartonella Infections, Including Cat-Scratch Disease, Michael Giladi, Moshe Ephros
161. Donovanosis, Nigel O'Farrell

Section 7: Miscellaneous Bacterial Infections

162. Nocardiosis, Gregory A. Filice
163. Actinomycosis, Thomas A. Russo
164. Infections Due to Mixed Anaerobic Organisms, Dennis L. Kasper, Ronit Cohen-Poradosu

Section 8: Mycobacterial Diseases

165. Tuberculosis, Mario C. Raviglione, Richard J. O'Brien
166. Leprosy, Robert H. Gelber
167. Nontuberculous Mycobacterial Infections, Steven M. Holland
168. Antimycobacterial Agents, Max R. O'Donnell, Jussi J. Saukkonen

Section 9: Spirochetal Diseases

169. Syphilis, Sheila A. Lukehart
170. Endemic Treponematoses, Sheila A. Lukehart
171. Leptospirosis, Joseph M. Vinetz
172. Relapsing Fever, Mark S. Dworkin
173. Lyme Borreliosis, Allen C. Steere

Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae

174. Rickettsial Diseases, David H. Walker, J. Stephen Dumler, Thomas Marrie
175. Infections Due to Mycoplasmas, R. Doug Hardy
176. Chlamydial Infections, Charlotte A. Gaydos, Thomas C. Quinn

Section 11: Viral Diseases: General Considerations

177. Medical Virology, Fred Wang, Elliott Kieff
178. Antiviral Chemotherapy, Excluding Antiretroviral Drugs, Lindsey R. Baden, Raphael Dolin

Section 12: Infections Due to DNA Viruses

179. Herpes Simplex Virus Infections, Lawrence Corey
180. Varicella-Zoster Virus Infections, Richard J. Whitley
181. Epstein-Barr Virus Infections, Including Infectious Mononucleosis, Jeffrey I. Cohen
182. Cytomegalovirus and Human Herpesvirus Types 6,7, and 8, Martin S. Hirsch
183. Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections, Fred Wang
184. Parvovirus Infections, Kevin E. Brown
185. Human Papillomavirus Infections, Richard C. Reichman

Section 13: Infections Due to DNA and RNA Respiratory Viruses

186. Common Viral Respiratory Infections, Raphael Dolin
187. Influenza, Raphael Dolin

Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses

188. The Human Retroviruses, Dan L. Longo
189. Human Immunodeficiency Virus Disease: AIDS and Related Disorders, Anthony S. Fauci, H. Clifford Lane

Section 15: Infections Due to RNA Viruses

190. Viral Gastroenteritis, Umesh D. Parashar, Roger I. Glass
191. Enteroviruses and Reoviruses, Jeffrey I. Cohen
192. Measles (Rubeola), William J. Moss
193. Rubella (German Measles), Laura A. Zimmerman, Susan E. Reef
194. Mumps, Steven Rubin, Kathryn M. Carbone
195. Rabies and Other Rhabdovirus Infections, Alan C. Jackson
196. Infections Caused by Arthropod- and Rodent-Borne Viruses, Clarence J. Peters
197. Ebola and Marburg Viruses, Clarence J. Peters

Section 16: Fungal Infections

198. Diagnosis and Treatment of Fungal Infections, John E. Edwards, Jr.
199. Histoplasmosis, Chadi A. Hage, L. Joseph Wheat
200. Coccidioidomycosis, Neiil M. Ampel
201. Blastomycosis, Stanley W. Chapman, Donna C. Sullivan
202. Cryptococcosis, Arturo Casadevall
203. Candidiasis, John E. Edwards, Jr.
204. Aspergillosis, David W. Denning
205. Mucormycosis, Brad Spellberg, Ashraf S. Ibrahim
206. Superficial Mycoses and Less Common Systemic Mycoses, Carol A. Kauffman
207. Pneumocystis Infections, A. George Smulian, Peter D. Walzer

Section 17: Protozoal and Helminthic Infections: General Considerations

e25. Laboratory Diagnosis of Parasitic Infections, Sharon L. Reed, Charles E. Davis
208. Agents Used to Treat Parasitic Infections, Thomas A. Moore
e26. Pharmacology of Agents Used to Treat Parasitic Infections, Thomas A. Moore

Section 18: Protozoal Infections

209. Amebiasis and Infection With Free-Living Amebas, Samuel L. Stanley, Jr.
210. Malaria, Nicholas J. White, Joel G. Berman
211. Babesiosis, Edouard Vannier, Jeffrey A. Gelfand
e27. Atlas of Blood Smears of Malaria and Babesiosis, Nicholas J. White, Joel G. Breman
212. Leishmaniasis, Shyam Sundar
213. Chagas' Disease and Trypanosomiasis, Louis V. Kirchhoff, Anis Rassi, Jr.
214. Toxoplasma Infections, Kami Kim, Lloyd H. Kasper
215. Protozoal Intestinal Infections and Trichomoniasis, Peter F. Weller

Section 19: Helminthic Infections

216. Trichinellosis and Other Tissue Nematode Infections, Peter F. Weller
217. Intestinal Nematode Infections, Peter F. Weller, Thomas B. Nutman
218. Filarial and Related Infections, Thomas B. Nutman, Peter F. Weller
219. Schistosomiasis and Other Trematode Infections, Adel A.F. Mahmoud
220. Cestode Infections, A. Clinton White, Jr., Peter F. Weller

PART 9: TERRORISM AND CLINICAL MEDICINE

221. Microbial Bioterrorism, H. Clifford Lane, Anthony S. Fauci
222. Chemical Terrorism, Charles G. Hurst, Jonathan Newmark, James A. Romano, Jr.
223. Radiation Terrorism, Zelig A. Tochner, Eli Glatstein

PART 10: DISORDERS OF THE CARDIOVASCULAR SYSTEM
Section 1: Introduction to Cardiovascular Disorders

224. Basic Biology of the Cardiovascular System, Joseph Loscalzo, Peter Libby, Jonathan Epstein
225. Epidemiology of Cardiovascular Disease, Thomas A. Gaziano, J. Michael Gaziano
226. Approach to the Patient with Possible Cardiovascular Disease, Joseph Loscalzo

Section 2: Diagnosis of Cardiovascular Disorders

227. Physical Examination of the Cardiovascular System, Patrick T. O'Gara, Joseph Loscalzo
228. Electrocardiography, Ary L. Goldberger
e28. Atlas of Electrocardiography, Ary L. Goldberger
229. Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging, Rick A. Nishimura, Panithaya Chareonthaitawee, Matthew Martinez
e29. Atlas of Noninvasive Cardiac Imaging, Rick A. Nishimura, Panithya Chareonthaitawee, Matthew Martinez
230. Diagnostic Cardiac Catherization and Coronary Angiography, Jane A. Leopold, David P. Faxon

Section 3: Disorders of Rhythm

231. Principles of Electrophysiology, David D. Spragg, Gordon F. Tomaselli
232. The Bradyarrhythmias, Gordon F. Tomaselli
233. The Tachyarrhythmias, Francis Marchlinski
e30. Atlas of Cardiac Arrhythmias, Ary L. Golberger

Section 4: Disorders of the Heart

234. Heart Failure and Cor Pulmonale, Douglas L. Mann, Murali Chakinala
235. Cardiac Transplantation and Prolonged Assisted Circulation, Sharon A. Hunt, Hari R. Mallidi
236. Congenital Heart Disease in the Adult, John S. Child, Jamil Aboulhosn
237. Valvular Heart Disease, Patrick O'Gara, Joseph Loscalzo
238. Cardiomyopathy and Myocarditis, Lynne Warner Stevenson, Joseph Loscalzo
239. Pericardial Disease, Eugene Braunwald
240. Tumors and Trauma of the Heart, Eric H. Awtry, Wilson S. Colucci
e31. Cardiac Manifestations of Systemic Disease, Eric H. Awtry, Wilson S. Colucci

Section 5: Vascular Disease

241. The Pathogenesis, Prevention, and Treatment of Atherosclerosis, Peter Libby
e32. Atlas of Atherosclerosis, Peter Libby
242. The Metabolic Sydrome, Robert H. Eckel
243. Ischemic Heart Disease, Elliott M. Antman, Andrew P. Selwyn, Joseph Loscalzo
244. Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction, Christopher P. Cannon
245. ST-Segment Elevation Myocardial Infarction, Elliott M. Antman, Joseph Loscalzo
246. Percutaneous Coronary Interventions and Other Interventional Procedures, David P. Faxon, Deepak L. Bhatt
e33. Atlas of Percutaneous Revascularization, Jane A. Leopold, Deepak L. Bhatt, David P. Faxon
247. Hypertensive Vascular Disease, Theodore A. Kotchen
248. Diseases of the Aorta, Mark A. Creager, Joseph Loscalzo
249. Vascular Diseases of the Extremities, Mark A. Creager, Joseph Loscalzo
250. Pulmonary Hypertension, Stuart Rich

PART 11: DISORDERS OF THE RESPIRATORY SYSTEM
Section 1: Diagnosis of Respiratory Disorders

251. Approach to the Patient With Disease of the Respiratory System, Patricia Kritek, Augustine Choi
252. Disturbances of Respiratory Function, Edward T. Naureckas, Julian Solway
253. Diagnostic Procedures in Respiratory Disease, Anne L. Fuhlbrigge, Augustine M. K. Choi
e34. Atlas of Chest Imaging, Patricia Kritek, John J. Reilly, Jr.

Section 2: Diseases of the Respiratory System

254. Asthma, Peter J. Barnes
255. Hypersensitivity Pneumonitis and Pulmonary Infiltrates With Eosinophilia, Alica K. Gerke, Gary W. Hunninghake
256. Occupational and Environmental Lung Disease, John R. Balmes, Frank E. Speizer
257. Pneumonia, Lionel A. Mandell, Richard Wunderink
258. Bronchiectasis and Lung Abscess, Rebecca M. Baron and John G. Bartlett
259. Cystic Fibrosis, Richard C. Boucher
260. Chronic Obstructive Pulmonary Disease, John J. Reilly, Jr., Edwin K. Silverman, Steven D. Shapiro
261. Interstitial Lung Diseases, Talmadge E. King, Jr.
262. Deep Venous Thrombosis and Pulmonary Thromboembolism, Samuel Z. Goldhaber
263. Disorders of the Pleura and Mediastinum, Richard W. Light
264. Disorders of Ventilation, John F. McConville, Julian Solway
265. Sleep Apnea, Neil J. Douglas
266. Lung Transplantation, Elbert P. Trulock

PART 12: CRITICAL CARE MEDICINE
Section 1: Respiratory Critical Care

267. Approach to the Patient With Critical Illness, John P. Kress, Jesse B. Hall
268. Acute Respiratory Distress Syndrome, Bruce D. Levy, Augustine M.K. Choi
269. Mechanical Ventilatory Support, Bartolome R. Celli

Section 2: Shock and Cardiac Arrest

270. Approach to the Patient With Shock, Ronald V. Maier
271. Severe Sepsis and Septic Shock, Robert S. Munford
272. Cardiogenic Shock and Pulmonary Edema, Judith S. Hochman, David H. Ingbar
273. Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death, Robert J. Myerburg, Agustin Castellanos

Section 3: Neurologic Critical Care

274. Coma, Allan H. Ropper
275. Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy, and Subarachnoid Hemorrhage, J. Claude Hemphill, III, Wade S. Smith, Daryl R. Gress

Section 4: Oncologic Emergencies

276. Oncologic Emergencies, Rasim Gucalp, Janice Dutcher

PART 13: DISORDERS OF THE KIDNEY AND URINARY TRACT

277. Cellular and Molecular Biology of the Kidney, Alfred L. George, Jr., Eric G. Neilson
278. Adaptation of the Kidney to Renal Injury, Raymond C. Harris, Eric G. Neilson
279. Acute Kidney Injury, Sushrut S. Waikar, Joseph V. Bonventre
280. Chronic Kidney Disease, Joanne M. Bargman, Karl Skorecki
281. Dialysis in the Treatment of Renal Failure, Kathleen D. Liu, Glenn M. Chertow
282. Transplantation in the Treatment of Renal Failure, Anil Chandraker, Edgar L. Milford, Mohamed H. Sayegh
283. Glomerular Diseases, Julia B. Lewis, Eric G. Neilson
284. Polycystic Kidney Disease and Other Inherited Tubular Disorders, David J. Salant, Craig E. Gordon
285. Tubulointerstitial Diseases of the Kidney, Laurence H. Beck, Jr., David J. Salant
286. Vascular Injury to the Kidney, Stephen C. Textor, Nelson Leung
287. Nephrolithiasis, John R. Asplin, Fredric L. Coe, Murray J. Favus
288. Urinary Tract Infections, Pyelonephritis, and Prostatitis, Barbara W. Trautner, Kalpana Gupta
e35. Interstitial Cystitis/Painful Bladder Syndrome, John W. Warren
289. Urinary Tract Obstruction, Julian L. Seifter

PART 14: DISORDERS OF THE GASTROINTESTINAL SYSTEM
Section 1: Disorders of the Alimentary Tract

290. Approach to the Patient With Gastrointestinal Disease, William L. Hasler, Chung Owyang
291. Gastrointestinal Endoscopy, Louis Michel Wong Kee Song, Mark Topazian
e36. Video Atlas of Gastrointestinal Endoscopy, Louis Michel Wong Kee Song, Mark Topazian
292. Diseases of the Esophagus, Peter J. Kahrilas, Ikuo Hirano
293. Peptic Ulcer Disease and Related Disorders, John Del Valle
294. Disorders of Absorption, Henry J. Binder
e37. The Schilling Test, Henry J. Binder
295. Inflammatory Bowel Disease, Sonia Friedman, Richard S. Blumberg
296. Irritable Bowel Syndrome, Chung Owyang
297. Diverticular Disease and Common Anorectal Disorders, Susan L. Gearhart
298. Mesenteric Vascular Insufficiency, Susan L. Gearhart
299. Acute Intestinal Obstruction, William Silen
300. Acute Appendicitis and Peritonitis, William Silen

Section 2: Liver and Biliary Tract Disease

301. Approach to the Patient With Liver Disease, Marc Ghany, Jay H. Hoofnagle
302. Evaluation of Liver Function, Daniel S. Pratt, Marshall M. Kaplan
303. The Hyperbilirubinemias, Allan W. Wolkoff
304. Acute Viral Hepatitis, Jules L. Dienstag
305. Toxic and Drug-Induced Hepatitis, Jules L. Dienstag
306. Chronic Hepatitis, Jules L. Dienstag
307. Alcoholic Liver Disease, Mark E. Mailliard, Michael F. Sorrell
308. Cirrhosis and Its Complications, Bruce R. Bacon
e38. Atlas of Liver Biopsies, Jules L. Dienstag, Atul K. Bhan
309. Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver, Bruce R. Bacon
310. Liver Transplantation, Jules L. Dienstag, Raymond T. Chung
311. Diseases of the Gallbladder and Bile Ducts, Norton J. Greenberger, Gustav Paumgartner

Section 3: Disorders of the Pancreas

312. Approach to the Patient with Pancreatic Disease, Norton J. Greenberger, Darwin L. Conwell, Peter A. Banks
313. Acute and Chronic Pancreatitis, Norton J. Greenberger, Darwin L. Conwell, Bechien U. Wu, and Peter A. Banks

PART 15: DISORDERS OF THE JOINTS AND ADJACENT TISSUES
Section 1: The Immune System in Health and Disease

314. Introduction to the Immune System, Barton F. Haynes, Kelly A. Soderberg, and Anthony S. Fauci
315. The Major Histocompatibility Complex, Gerald T. Nepom
316. Primary Immune Deficiency Diseases, Alain Fischer
e39. Primary Immunodeficiencies Associated With (or Secondary to) Other Diseases, Alain Fischer

Section 2: Disorders of Immune-Mediated Injury

317. Allergies, Anaphylaxis, and Systemic Mastocytosis, K. Frank Austen
318. Autoimmunity and Autoimmune Diseases, Betty Diamond, Peter E. Lipsky
319. Systemic Lupus Erythematosus, Bevra Hannahs Hahn
320. Antiphospholipid Antibody Syndrome, Haralampos M. Moutsopoulos, Panayiotis G. Vlachoyiannopoulos
321. Rheumatoid Arthritis, Ankoor Shah, E. William St. Clair
322. Acute Rheumatic Fever, Jonathan R. Carapetis
323. Systemic Sclerosis (Scleroderma) and Related Disorders, John Varga
324. Sjogren's Syndrome, Haralampos M. Moutsopoulos, Athanasio G. Tzioufas
325. The Spondyloarthritides, Joel D. Taurog
326. The Vasculitis Syndromes, Carol A. Langford, Anthony S. Fauci
e40. Atlas of the Vasculitic Syndromes, Carol A. Langford, Anthony S. Fauci
327. Behcet's Syndrome, Haralampos M. Moutsopoulos
328. Relapsing Polychondritis, Carol A. Langford
329. Sarcoidosis, Robert P. Baughman, Elyse E. Lower
330. Familial Mediterranean Fever and Other Hereditary Recurrent Fevers, Daniel L. Kastner

Section 3: Disorders of the Joints and Adjacent Tissues

331. Approach to Articular and Musculoskeletal Disorders, John J. Cash, Peter E. Lipsky
332. Osteoarthritis, David T. Felson
333. Gout and Other Crystal-Associated Arthropathies, H. Ralph Schumacher, Lan X. Chen
334. Infectious Arthritis, Lawrence C. Madoff
335. Fibromyalgia, Leslie J. Crofford
336. Arthritis Associated With Systemic Disease, and Other Arthritides, Carol A. Langford, Brian F. Mandell
337. Periarticular Disorders of the Extremities, Carol A. Langford, Bruce C. Gilliland

PART 16: ENDOCRINOLOGY AND METABOLISM
Section 1: Endocrinology

338. Principles of Endocrinology, J. Larry Jameson
339. Disorders of the Anterior Pituitary and Hypothalamus, Shlomo Melmed, J. Larry Jameson
340. Disorders of the Neurohypophysis, Gary L. Robertson
341. Disorders of the Thyroid Gland, J. Larry Jameson, Anthony P. Weetman
342. Disorders of the Adrenal Cortex, Wiebke Arlt
343. Pheochromocytoma, Hartmut P.H. Neumann
344. Diabetes Mellitus, Alvin C. Powers
345. Hypoglycemia, Philip E. Cryer, Stephen N. Davis
346. Disorders of the Testes and Male Reproductive System, Shalender Bhasin, J. Larry Jameson
347. The Female Reproductive System, Infertility, and Contraception
348. The Menopause Transition and Postmenopausal Hormone Therapy, JoAnn E. Manson, Shari S. Bassuk
349. Disorders of Sex Development, John C. Achermann, J. Larry Jameson
350. Endocrine Tumors of the Gastrointestinal Tract and Pancreas, Robert T. Jensen
351. Disorders Affecting Multiple Endocrine Systems, Camilo Jimenez Vasquez, Robert F. Gagel

Section 2: Disorders of Bone and Mineral Metabolism

352. Bone and Mineral Metabolism in Health and Disease, F. Richard Bringhurst, Marie B. Demay, Stephen M. Krane, Henry M. Kronenberg
353. Disorders of the Parathyroid Gland and Calcium Homeostasis, John T. Potts, Harald Juppner
354. Osteoporosis, Robert Lindsay, Felicia Cosman
355. Paget's Disease and Other Dysplasias of Bone, Murray J. Favus, Tamara J. Vokes

Section 3: Disorders of Intermediary Metabolism

356. Disorders of Lipoprotein Metabolism, Daniel J. Rader, Helen H. Hobbs
357. Hemochromatosis, Lawrie W. Powell
358. The Porphyrias, Robert J. Desnick, Manisha Balwani
359. Disorders of Purine and Pyrimidine Metabolism, Christopher M. Burns, Robert L. Wortmann
360. Wilson's Disease, George J. Brewer
361. Lysosomal Storage Diseases, Robert J. Hopkin, Gregory A. Grabowski
362. Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism, Priya S. Kishnani, Yuan-Tsong Chen
363. Heritable Disorders of Connective Tissue, Darwin J. Prockop, John F. Bateman
364. Inherited Disorders of Amino Acid Metabolism in Adults, Nicola Longo
365. Inherited Defects of Membrane Transport, Nicola Longo
e41. Atlas of Clinical Manifestations of Metabolic Diseases, J. Larry Jameson

PART 17: NEUROLOGIC DISORDERS
Section 1: Diagnosis of Neurologic Disorders

366. Biology of Neurologic Diseases, Stephen L. Hauser, M. Flint Beal
367. Approach to the Patient with Neurologic Disease, Daniel H. Lowenstein, Joseph B. Martin, Stephen L. Hauser
e42. The Neuerological Screening Exam, Daniel H. Lowenstein
e43. Video Atlas of the Detailed Neurologic Examination, Martin A. Samuels
368. Neuroimaging in Neurologic Disorders, William P. Dillon
e44. Atlas of Neuroimaging, Andre Furtado, William P. Dillon
e45. Electrodiagnostic Studies of Nervous System Disorders: EEG, Evoked Potentials, and EMG, Michael J. Aminoff
e46. Technique of Lumbar Puncture, Elizabeth Robbins, Stephen L. Hauser

Section 2: Diseases of the Central Nervous System

369. Seizures and Epilepsy, Daniel H. Lowenstein
370. Cerebrovascular Diseases, Wade S. Smith, Joey D. English, S. Claiborne Johnston
371. Dementia, William W. Seeley, Bruce L. Miller
372. Parkinson's Disease and Other Movement Disorders, C. Warren Olanow, Anthony H.V. Schapira
373. Ataxic Disorders, Roger N. Rosenberg
374. Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases, Robert H. Brown, Jr.
375. Disorders of the Autonomic Nervous System, Phillip A. Low, John W. Engstrom
376. Trigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders, M. Flint Beal, Stephen L. Hauser
377. Diseases of the Spinal Cord, Stephen L. Hauser, Allan H. Ropper
378. Concussion and Other Head Injuries, Allan H. Ropper
379. Primary and Metastatic Tumors of the Nervous System, Lisa M. DeAngelis, Patrick Y. Wen
380. Multiple Sclerosis and Other Demyelinating Diseases, Stephen L. Hauser, Douglas S. Goodin
381. Meningitis, Encephalitis, Brain Abscess, and Empyema, Karen L. Roos, Kenneth L. Tyler
382. Chronic and Recurrent Meningitis, Walter J. Koroshetz, Morton N. Swartz
383. Prion Diseases, Stanley B. Prusiner, Bruce L. Miller

Section 3: Nerve and Muscle Disorders

384. Peripheral Neuropathy, Anthony A. Amato, Richard J. Barohn
385. Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies, Stephen L. Hauser, Anthony A. Amato
386. Myasthenia Gravis and Other Diseases of the Neuromuscular Junction, Daniel B. Drachman
387. Muscular Dystrophies and Other Muscle Diseases, Anthony A. Amato, Robert H. Brown, Jr.
388. Polymyositis, Dermatomyositis, and Inclusion Body Myositis, Marinos C. Dalakas
e47. Special Issues in Inpatient Neurologic Consultation, S. Andrew Josephson, Martin A. Samuels

Section 4: Chronic Fatigue Syndrome

389. Chronic Fatigue Syndrome, Gijs Bleijenberg, Jos W.M. van der Meer

Section 5: Psychiatric Disorders

390. Biology of Psychiatric Disorders, Robert O. Messing, John H. Rubinstein, Eric J. Nestler
391. Mental Disorders, Victor I. Reus

Section 6: Alcoholism and Drug Dependency

392. Alcohol and Alcoholism, Marc A. Schuckit
393. Opioid Drug Abuse and Dependence, Thomas R. Kosten
394. Cocaine and Other Commonly Abused Drugs, Nancy K. Mello, Jack H. Mendelson
395. Nicotine Addiction, David M. Burns
e48. Neuropsychiatric Illnesses in War Veterans, Charles W. Hoge

PART 18: POISONING, DRUG OVERDOSE, AND ENVENOMATION

e49. Heavy Metal Poisoning, Howard Hu
e50. Poisoning and Drug Overdosage, Mark B. Mycyk
396. Disorders Caused by Venomous Snakebites and Marine Animal Exposures, Paul S. Auerbach, Robert L. Norris
397. Ectoparasite Infestations and Arthropod Bites and Stings, Richard J. Pollock

PART 19: HIGH ALTITUDE AND DECOMPRESSION SICKNESS

e51. Altitude Illness, Buddha Basnyat, Geoffrey Tabin
e52. Hyperbaric and Diving Medicine, Michael H. Bennett, Simon J. Mitchell
APPENDIX: LABORATORY VALUES OF CLINICAL IMPORTANCE
Alexander Kratz, Michael A. Pesce, Robert C. Basner, Andrew J. Einstein
e53. The Clinical Laboratory in Modern Health Care, Anthony A. Killeen
e54. Clinical Procedure Tutorial: Central Venous Catheter Placement, Maria A. Yialamas, William Corcoran, Gyorgy Frendl
e55. Clinical Procedure Tutorial: Thoracentesis, Charles A. Morris, Andrew Wolf
e56. Clinical Procedure Tutorial: Abdominal Paracentesis, Maria A. Yialamas, Anna Rutherford, Lindsay King
e57. Clinical Procedure Tutorial: Endotracheal Intubation, Charles A. Morris, Emily Nelson Maher

INDEX